No
Each of the neoStat V2 series, the neoStat V2, the neoStat-hw V2 and neoStat-e V2 will create a wireless mesh network back to the neoHub. There is no relationship whatsoever between the the wiring centres and the neoHub, it is all done through the thermostats.
This also applies with the V1 series of neoStats.
The battery powered neoAir thermostats do not repeat the mesh signal and will communicate directly to the neoHub, however if there are any hard wired neoStats in between, or repeaters such as neoPlugs, they will repeat the signal back to the neoHub.